* Hyperventilation syndrome often presents with chest pain and a tingling sensation of the fingertips and around the mouth
* Gastroesophageal reflux disease (GERD)
* Tietze's syndrome - a benign and harmless form of osteochondritis often mistaken for heart disease
* Bornholm disease - a viral disease that can mimic all of the above
* Several others
As in all medicine, a careful medical history and physical examination is essential is separating dangerous and trivial causes of disease, and the management of chest pain is often done on specialised units (termed medical assessment units) to concentrate the investigations. A rapid diagnosis can be life-saving and often has to be made without the help of X-rays or blood tests (e.g. aortic dissection).
An emergency medicine doctor will also focus on recent health changes, family history (premature atherosclerosis, cholesterol disorders), tobacco smoking.
* X-rays of the chest and/or abdomen (CT scanning may be better but is often not available)
* An electrocardiogram (ECG)
* V/Q scintigraphy (when a pulmonary embolism is suspected)
* Blood tests:
o Full blood count
o Electrolytes and renal function (creatinine)
o Liver enzymes
o Troponin I or T (to indicate myocardial damage)
o D-dimer (when suspicion for pulmonary embolism is present but low)
In finding the cause, the history given by the patient is often the most important tool. In angina pectoris, for example, blood tests and other analyses are not sensitive enough (Chun & McGee 2004). Often, no definite cause will be found, and the focus in these cases is on excluding severe diseases and reassuring the patient. If acute coronary syndrome ("unstable angina") is suspected, many patients are admitted briefly for observation and determination of cardiac enzyme levels (CK-MB or troponin).
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